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Among solid tumors, the clinical significance of the proliferation index on breast cancer has been extensively studied. Mitotic counting has also been shown in multiple studies to have prognostic value in breast cancer, where a lower count of mitotic cells correlates with a more favorable outcome, and thus has been incorporated into part of the ...
An elevated mitotic index indicates more cells are dividing. In cancer cells, the mitotic index may be elevated compared to normal growth of tissues or cellular repair of the site of an injury. [2] The mitotic index is therefore an important prognostic factor predicting both overall survival and response to chemotherapy in most types of cancer ...
Furthermore, the 2022 WHO classification introduces a two-tiered grading system for medullary thyroid carcinomas based on mitotic count, Ki-67 index and the absence or presence of tumor necrosis. Here, it may be noted that different cut-offs than with tumors of gastrointestinal, aerodigestive and lung origin are applied.
Nutritional problems are also frequently seen in cancer patients at diagnosis and through chemotherapy treatment. Research suggests that in children and young people undergoing cancer treatment, parenteral nutrition may help with this leading to weight gain and increased calorie and protein intake, when compared to enteral nutrition. [138]
The underlying purpose of staging is to describe the extent or severity of an individual's cancer, and to bring together cancers that have similar prognosis and treatment. [22] Staging of breast cancer is one aspect of breast cancer classification that assists in making appropriate treatment choices, when considered along with other ...
If 5 or more mitotic figures are present in 10 high powered fields but the behavior still appears benign, may append “with significant mitotic activity”. Moderate to severe atypia without tumor cell necrosis atypical leiomyoma if < 10 mitotic figures per high power field or; leiomyosarcoma if ≥ 10 mitotic figures per high power field
Promotion of mitotic catastrophe in cancer cells is an area of cancer therapeutic research that has garnered interest and is seen as a potential target to overcome resistance developed to current chemotherapies. [4] Cancer cells have been found to be more sensitive to mitotic catastrophe induction than non-cancerous cells in the body. [3]
Mitotic inhibitors are used in cancer treatment, because cancer cells are able to grow through continuous division that eventually spread through the body (metastasize). Thus, cancer cells are more sensitive to inhibition of mitosis than normal cells.