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  2. Glycopeptide antibiotic - Wikipedia

    en.wikipedia.org/wiki/Glycopeptide_antibiotic

    Some other side-effects of vancomycin are nephrotoxicity including kidney failure and interstitial nephritis, blood disorders including neutropenia, and deafness, which is reversible once therapy has stopped. Over 90% of the dose is excreted in the urine, therefore there is a risk of accumulation in patients with renal impairment, so ...

  3. Vancomycin - Wikipedia

    en.wikipedia.org/wiki/Vancomycin

    Vancomycin is a glycopeptide antibiotic medication used to treat certain bacterial infections. [7] It is administered intravenously (injection into a vein) to treat complicated skin infections, bloodstream infections, endocarditis, bone and joint infections, and meningitis caused by methicillin-resistant Staphylococcus aureus. [8]

  4. Drug of last resort - Wikipedia

    en.wikipedia.org/wiki/Drug_of_last_resort

    Such placement may result from a multitude of considerations, including greater efficacy of other agents, socioeconomic considerations, availability issues, unpleasant side effects or similar issues relating to patient tolerance. Some experimental therapies might also be called drugs of last resort when administered following the failure of all ...

  5. Biological half-life - Wikipedia

    en.wikipedia.org/wiki/Biological_half-life

    Absorption half-life 1 h, elimination half-life 12 h. Biological half-life ( elimination half-life , pharmacological half-life ) is the time taken for concentration of a biological substance (such as a medication ) to decrease from its maximum concentration ( C max ) to half of C max in the blood plasma .

  6. Therapeutic index - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_index

    The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose.It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1]

  7. Pharmacodynamics - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics

    The therapeutic window is the amount of a medication between the amount that gives an effect (effective dose) and the amount that gives more adverse effects than desired effects. For instance, medication with a small pharmaceutical window must be administered with care and control, e.g. by frequently measuring blood concentration of the drug ...

  8. Complications of diabetes - Wikipedia

    en.wikipedia.org/wiki/Complications_of_diabetes

    The complications of diabetes can dramatically impair quality of life and cause long-lasting disability. Overall, complications are far less common and less severe in people with well-controlled blood sugar levels. [3] [4] [5] Some non-modifiable risk factors such as age at diabetes onset, type of diabetes, gender, and genetics may influence risk.

  9. Effective half-life - Wikipedia

    en.wikipedia.org/wiki/Effective_half-life

    Alternatively, since the radioactive decay contributes to the "physical (i.e. radioactive)" half-life, while the metabolic elimination processes determines the "biological" half-life of the radionuclide, the two act as parallel paths for elimination of the radioactivity, the effective half-life could also be represented by the formula: [1] [2]

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