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EFSA and JECFA reviewed a feeding study in rats and both authorities recognized that the no adverse effect level for spilanthol was 572 mg/kg b.w./day, yielding a safe dose of spilanthol of 1.9 mg/kg b.w./day, or 133.5 mg/70-kg-male/day, 111 mg/58-kg-female/day, or 38 mg/20-kg-child/day.
Spilanthol (affinin) is a fatty acid amide isolated from Acmella oleracea. [1] It is believed to be responsible for the local anesthetic properties of the plant. [2]Spilanthol permeates the human skin [3] and the inside lining of the cheeks in the mouth (buccal mucosa), [4] resulting in local as well as systemic pharmacological concentrations.
Numerous species once included in Spilanthes are now considered members of other genera. The best known of these is the toothache plant, which was formerly Spilanthes acmella but is now considered part of its own genus and is referred to as Acmella oleracea. [7] Other taxa formerly included in Spilanthes include: [3] Adenostemma; Eclipta ...
The answer isn't exactly straightforward.
Paterson's Curse has been responsible for the deaths of many horses.. Many plants are poisonous to equines; the species vary depending on location, climate, and grazing conditions.
phenylpropanolamine – controls urinary incontinence in dogs; phenytoin/pentobarbital – animal euthanasia product containing phenytoin and pentobarbital; pimobendan – phosphodiesterase 3 inhibitor used to manage heart failure in dogs; pirlimycin – antimicrobial; ponazuril – anticoccidial
For example, 0.4 oz (11 g) of baker's chocolate would be enough to produce mild symptoms in a 20 lb (9.1 kg) dog, while a 25% cacao chocolate bar (like milk chocolate) would be only 25% as toxic as the same dose of baker's chocolate. [15] One ounce of milk chocolate per pound of body weight (63 g/kg) is a potentially lethal dose in dogs. [14]
The median lethal dose of theobromine for dogs is 100–200 mg/kg (0.0016–0.0032 oz/lb); therefore, a 10 kg (22 lb) dog would need to consume a minimum of 200 g (7.1 oz) of the most theobromine-rich (5 g/kg (0.080 oz/lb)) dark chocolate, or a maximum of 1 kg (2.2 lb) (of theobromine-rich milk chocolate), to have a 50% chance of receiving a ...
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