enow.com Web Search

Search results

  1. Results from the WOW.Com Content Network
  2. Acid dissociation constant - Wikipedia

    en.wikipedia.org/wiki/Acid_dissociation_constant

    Pauling's second rule is that the value of the first pK a for acids of the formula XO m (OH) n depends primarily on the number of oxo groups m, and is approximately independent of the number of hydroxy groups n, and also of the central atom X. Approximate values of pK a are 8 for m = 0, 2 for m = 1, −3 for m = 2 and < −10 for m = 3. [28]

  3. Ion trapping - Wikipedia

    en.wikipedia.org/wiki/Ion_trapping

    The converse is true in a basic medium. For example, Naproxen is a non-steroidal anti-inflammatory drug that is a weak acid (its pKa value is 5.0). The gastric juice has a pH of 2.0. It is a three-fold difference (due to log scale) between its pH and its pKa; therefore there is a 1000× difference between the charged and uncharged concentrations.

  4. Mycophenolic acid - Wikipedia

    en.wikipedia.org/wiki/Mycophenolic_acid

    Mycophenolate mofetil is reported to have a pKa values of 5.6 for the ... and given the name mycophenolic acid. ... In 1981 he decided to go for drug discovery and ...

  5. Lists of drugs - Wikipedia

    en.wikipedia.org/wiki/Lists_of_drugs

    Many drugs have more than one name and, therefore, the same drug may be listed more than once. Brand names and generic names are differentiated by capitalizing brand names. See also the list of the top 100 bestselling branded drugs , ranked by sales.

  6. Metformin - Wikipedia

    en.wikipedia.org/wiki/Metformin

    Metformin has acid dissociation constant values (pK a) of 2.8 and 11.5, so it exists very largely as the hydrophilic cationic species at physiological pH values. The metformin pK a values make it a stronger base than most other basic medications with less than 0.01% nonionized in blood.

  7. Drug nomenclature - Wikipedia

    en.wikipedia.org/wiki/Drug_nomenclature

    Drug nomenclature is the systematic naming of drugs, especially pharmaceutical drugs.In the majority of circumstances, drugs have 3 types of names: chemical names, the most important of which is the IUPAC name; generic or nonproprietary names, the most important of which are international nonproprietary names (INNs); and trade names, which are brand names. [1]

  8. Pyrazole - Wikipedia

    en.wikipedia.org/wiki/Pyrazole

    Pyrazole moieties are listed among the highly used ring systems for small molecule drugs by the US FDA [19] 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is used in the manufacture of six commercial fungicides which are inhibitors of succinate dehydrogenase. [20] [21]

  9. Rabeprazole - Wikipedia

    en.wikipedia.org/wiki/Rabeprazole

    The pKa (the pH at which 50% of the drug becomes positively charged) of rabeprazole is around 5.0, meaning that it doesn't take a lot of acid to activate it. While this theoretically translates into a faster onset of action for rabeprazole's acid-inhibiting effect, the clinical implications of this fact have yet to be elucidated. [ 11 ]