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Isotretinoin, also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication used to treat skin diseases like harlequin-type ichthyosis, and lamellar ichthyosis, and severe cystic acne or moderate acne that is unresponsive to antibiotics. [6]
Bremner's research used PET brain imaging to show a decrease in frontal lobe brain function in acne patients treated with Accutane (isotretinoin). He was an expert witness in litigation related to the relationship between Accutane and suicide and depression, including the case of Charles J. Bishop , [ 3 ] which he describes in the narrative non ...
Isotretinoin is a pharmaceutical derivative of retinoic acid (a metabolite of vitamin A). Its mechanism of action is believed to involve reduction in the amount of sebum produced by sebaceous glands on the skin's surface.
The name isotretinoin is the same root tretinoin plus the prefix iso-. Regarding pronunciation, the following variants apply equally to both tretinoin and isotretinoin. Given that retinoic is pronounced / ˌ r ɛ t ɪ ˈ n oʊ ɪ k /, [43] [44] [42] [45] it is natural that / ˌ t r ɛ t ɪ ˈ n oʊ ɪ n / is a commonly heard pronunciation.
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Once a doctor decides a patient is a candidate for isotretinoin, [10] they counsel the patient to ensure they understand the drug and the potential side effects. Once the patient signs the necessary paperwork, their doctor will give them a patient ID number, ID card, and program educational materials.