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Syphilis Screening. This document translates screening guidance and clinical considerations from the USPSTF and CDC into a decision tree format to guide implementation. 1.
These comprehensive recommendations are the first published by CDC on laboratory testing for syphilis, which has traditionally been based on serologic algorithms to detect a humoral immune response to T. pallidum.
A presumptive diagnosis of syphilis requires use of two laboratory serologic tests: a nontreponemal test (i.e., Venereal Disease Research Laboratory [VDRL] or rapid plasma reagin [RPR] test) and a treponemal test (i.e., the T. pallidum passive particle agglutination [TP-PA] assay, various EIAs, chemiluminescence immunoassays [CIAs] and ...
Perform second treponemal assay: Syphilis Antibody, Treponema pallidum-Particle Agglutination (TP-PA), Serum. Untreated or recently treated syphilis. See CDC** guidelines for treatment. Follow rapid plasma reagin titers.
Syphilis Testing Algorithm. Testing for Treponema pallidum, the causative agent for syphilis, can be performed using either the traditional method or the reverse sequence screening method. An initial workup for syphilis includes either a nontreponemal screening assay followed by a confirmatory treponemal test (traditional sequence), or an ...
These comprehensive recommendations are the first published by CDC on laboratory testing for syphilis, which has traditionally been based on serologic algorithms to detect a humoral immune response to T. pallidum.
Diagnostic testing for syphilis should be performed on patients with signs or symptoms of infection. In addition, asymptomatic patients should be screened for syphilis if they are at high risk for having acquired disease or for transmitting disease to others.
Syphilis Testing Algorithm. Click here for topics associated with this algorithm. INDICATIONS FOR TESTING. Persons with signs or symptoms of syphilis infection Persons being tested for other STIs Asymptomatic persons for whom screening is indicated; refer to the CDC’s testing recommendations. Traditional Sequence Algorithm. PERFORM.
The traditional algorithm starts with a non-treponemal test (RPR or VDRL) which, if reactive, is followed by a confirmatory treponemal test (TPPA). In interpreting serologies, it is helpful to know which testing algorithm (traditional vs reverse) is being used in your lab.
Traditional screening algorithm: Screen with an initial nontreponemal test (eg, Venereal Disease Research Laboratory [VDRL] or rapid plasma reagin [RPR] test). If positive, confirm with a treponemal antibody detection test (eg, T pallidum particle agglutination [TP-PA] test).