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JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
JWH-007 [5] Naphthoylindole: 9.5 ± 4.5: 2.9 ± 2.6: CB 2 (3.3x) JWH-009: Naphthoylindole >10000: 141 ± 14: CB 2 (>70x) JWH-011: Naphthoylindole: JWH-015 [5] Naphthoylindole: 164 ± 22: 13.8 ± 4.6: CB 2 (12x) JWH-016: Naphthoylindole: 22 ± 1.5: 4.3 ± 1.6: CB 2 (5.1x) JWH-018 [5] Naphthoylindole: 9 ± 5: 2.9 ± 2.6: CB 2 (3.1x) JWH-019 ...
Chemical structure of JWH-018, a simple naphthoylindole. Naphthoylindoles are a class of synthetic cannabinoids. [1] Pharmacology.
An assortment of several designer drugs. Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal.
JWH-018, CP 47,497 and the C6, C8, and C9 homologues of CP 47,497 have been illegal in Germany since January 22, 2009. [ 130 ] [ 131 ] Since November 26, 2016, about 80–90% of the substances belonging to the group of synthetic cannabinoids are illegal in Germany as the law does not cover all chemical structures.
MDMB-4en-PINACA powder can range in color from white or yellow or brown or orange. The methyl 3,3-dimethylbutanoate "head" moiety of MDMB-4en-PINACA has been implicated in higher CB1 potency but also toxicity compared to other "head" moiety groups such as the naphthene "head" moiety of JWH-018 and AM-2201 and the 2,2,3,3-tetramethylcyclopropyl ...
JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB 1 and CB 2 receptors. It is the N -hexyl homolog of the more common synthetic cannabinoid compound JWH-018 .
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