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2. Celecoxib - Wikipedia

   en.wikipedia.org/wiki/Celecoxib

   Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). [7] It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis. [7]

3. Cyclooxygenase-2 inhibitor - Wikipedia

   en.wikipedia.org/wiki/Cyclooxygenase-2_inhibitor

   In the CLASS trial which compared Celebrex 800 mg/day to ibuprofen 2400 mg/day and diclofenac 150 mg/day for osteoarthritis or rheumatoid arthritis for six months, Celebrex was associated with significantly fewer upper gastrointestinal complications (0.44% vs. 1.27%, p = 0.04), with no significant difference in incidence of cardiovascular ...

4. Nonsteroidal anti-inflammatory drug - Wikipedia

   en.wikipedia.org/wiki/Nonsteroidal_anti...

   Pain relief starts soon after taking the first dose, and a full analgesic effect should normally be obtained within a week, whereas an anti-inflammatory effect may not be achieved (or may not be clinically assessable) for up to three weeks. If appropriate responses are not obtained within these times, another NSAID should be tried. [3]

5. Best arthritis pain relief cream of 2024, according to experts

   www.aol.com/lifestyle/arthritis-pain-relief...

   Cymbiotika Ultimate Pain Balm is the best pain relief cream for sensitive skin due to its powerful blend of natural ingredients and ability to provide fast and targeted relief for pain and discomfort.

6. The best muscle pain relief creams of 2025, according to ...

   www.aol.com/lifestyle/best-muscle-pain-relief...

   Cost: $7 | Active ingredients: Lidocaine | Type: Cream | Amount: 4.3 ounces. Lidocaine is another popular ingredient found in pain relief creams. It's a topical anesthetic that's often used to ...

7. Discovery and development of cyclooxygenase 2 inhibitors

   en.wikipedia.org/wiki/Discovery_and_development...

   The impetus for development of selective COX-2 inhibitors was the adverse gastrointestinal side-effects of NSAIDs.Soon after the discovery of the mechanism of action of NSAIDs, strong indications emerged for alternative forms of COX, but little supporting evidence was found.