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Common side effects of testosterone include acne, swelling, and breast enlargement in men. [9] Serious side effects may include liver toxicity, heart disease, and behavioral changes. [9] Women and children who are exposed may develop masculinization. [9] It is recommended that individuals with prostate cancer should not use the medication. [9]
A 2014 review said there was some evidence men with certain comorbidities may be at risk of adverse effects including sleep apnoea, metabolic syndrome and cardiovascular disease. [29] Exogenous testosterone may also cause suppression of spermatogenesis, leading to, in some cases, infertility. [30]
As of 2016, the International Society for the Study of the Aging Male defines late-onset hypogonadism as a series of symptoms in older adults related to testosterone deficiency that combines features of both primary and secondary hypogonadism; the European Male Aging Study (a prospective study of ~3000 men) [10] defined the condition by the presence of at least three sexual symptoms (e.g ...
The FDA has recommended that all testosterone supplements carry a warning that they may increase the risk of heart attack and stroke.
Testosterone supplementation is also known to reduce the threshold for aggressive behavior in men. [9] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).
Because it lacks estrogenic effects, mesterolone may be indicated for treating cases of androgen deficiency in which breast tenderness or gynecomastia is also present. [14] The drug is described as a relatively weak androgen with partial activity and is rarely used for the purpose of androgen replacement therapy , but is still widely used in ...
These side effects may occur in as many as 90% of men treated with bicalutamide monotherapy, [29] but gynecomastia is generally reported to occur in 70 to 80% of patients. [30] In the EPC trial, at a median follow-up of 7.4 years, breast pain and gynecomastia respectively occurred in 73.6% and 68.8% of men treated with 150 mg/day bicalutamide ...
Upon analysis, scientists found that participants who stayed on standard statin treatment for their lifetime increased their quality-adjusted life years by 0.24-0.70, and those on higher-intensity ...
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