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Zinc pyrithione (or pyrithione zinc) is a coordination complex of zinc. It has fungistatic (inhibiting the division of fungal cells) and bacteriostatic (inhibiting bacterial cell division) properties and is used in the treatment of seborrhoeic dermatitis [ 2 ] and dandruff .
Like selenium sulfide, zinc pyrithione (a zinc complex with two chelating pyrithione anions) also reduces epidermal turnover and inhibits fungal growth. [3] [unreliable medical source?] It is often administered with ketoconazole for better results. The symptoms do not resolve completely even after prolonged medication.
The increased water content in gels increases the chances of microbial or fungal attack, [5] [8] which may contaminate the gel, making it unsuitable for use. Considering the direct route of administration, drugs must be very small in size to have an effective plasma concentration for action.
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Pyrithione is the common name of an organosulfur compound with molecular formula C 5 H 5 NOS, chosen as an abbreviation of pyridinethione, and found in the Persian shallot. [4] It exists as a pair of tautomers, the major form being the thione 1-hydroxy-2(1H)-pyridinethione and the minor form being the thiol 2-mercaptopyridine N-oxide; it crystallises in the thione form. [5]
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Three classes of barrier creams are used: water repellent creams, water-soluble creams, and creams designed for special applications. [4] Barrier creams may contain substances such as zinc oxide, talc or kaolin to layer over the skin. [5] For hand care they are designed to protect against the harm from detergents and other irritants. [6]
Water contaminated by aluminium or zinc cannot be treated in this way using a strong alkali as higher pHs re-dissolve the metal salts. Salt is difficult to remove except by reverse osmosis or distillation. Most portable treatment processes focus on mitigating human pathogens for safety and removing particulates matter, tastes and odours.
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