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Measures to remove potassium from the body include diuretics such as furosemide, potassium-binders such as polystyrene sulfonate (Kayexalate) and sodium zirconium cyclosilicate, and hemodialysis. [1] Hemodialysis is the most effective method. [3] Hyperkalemia is rare among those who are otherwise healthy. [6]
Potassium binders are medications that bind potassium ions in the gastrointestinal tract, thereby preventing its intestinal absorption. This category formerly consisted solely of polystyrene sulfonate, a polyanionic resin attached to a cation, administered either orally or by retention enema to patients who are at risk of developing hyperkalaemia (abnormal high serum potassium levels).
Polystyrene sulfonate is usually supplied in either the sodium or calcium form. It is used as a potassium binder in acute and chronic kidney disease for people with hyperkalemia (an abnormally high blood serum potassium level). [ 3 ]
Several approaches are used to treat hyperkalemia. [12] Other approved potassium binders in the United States include patiromer and sodium polystyrene sulfonate. [13] Hyperkalemia, particularly if severe, is a marker for an increased risk of death. [14] However, there is disagreement regarding whether a modestly elevated levels directly causes ...
A common group of medication that utilizes a combination of polystyrene and sulfonate functional groups are polystyrene sulfonates. [3] This medication is primarily used to treat hyperkalemia, a condition that results from an increased blood potassium level. [3] FDA approved equivalents of polystyrene sulfonates are KIONEX, KALEXATE, and SPS ...
Definitive treatment of hyperkalemia requires actual excretion of potassium, either through urine (which can be facilitated by administration of loop diuretics such as furosemide) or in the stool (which is accomplished by giving sodium polystyrene sulfonate enterally, where it will bind potassium in the GI tract.)
V03AB08 Sodium nitrite V03AB09 Dimercaprol ... V03AE Drugs for treatment of hyperkalemia and hyperphosphatemia. V03AE01 Polystyrene sulfonate V03AE02 Sevelamer
Mild hyperkalemia without symptoms can be treated with a loop diuretic and sodium polystyrene sulfonate, while a temporizing agent such as rapid acting insulin (in conjunction with glucose) and an agent to stabilize cardiac membranes such as calcium carbonate may be given in cases of severe hyperkalemia. [18]