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Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. [8] It is also effective for treating gastroenteritis. [9] [10] It can be given orally (by mouth), intramuscularly (injection into a muscle), or intravenously ...
Ondansetron (Zofran) is administered in an oral tablet form, orally dissolving tablet form, orally dissolving film, sublingual, or in an IV/IM injection. Tropisetron (Setrovel, Navoban) can be administered in oral capsules or in injection form. Palonosetron (Aloxi) can be administered in an injection or in oral capsules.
Ondansetron was approved by the U.S. Food and Drug Administration in 1991, and has since become available in several other countries, including the UK, Ireland, Australia, Canada, France and Brazil. As of 2008, ondansetron and granisetron are the only 5-HT 3 antagonists available as a generic drug in the United States. Ondansetron may be given ...
During an acute FPIES episode, if symptoms are mild (1-2 vomiting episodes), ondansetron or infacol may be given to control vomiting in children over 6 months of age, along with oral rehydration. If vomiting persists or if a child has more severe symptoms (i.e., lethargy, pallor, hypotonia), then the child should be taken to an emergency room ...
However, the use of ondansetron might possibly be linked to an increased rate of return to hospital in children. [69] The intravenous preparation of ondansetron may be given orally if clinical judgment warrants. [70] Dimenhydrinate, while reducing vomiting, does not appear to have a significant clinical benefit. [1]
Fasting guidelines often restrict the intake of any oral fluid 2-6 hours preoperatively, but in a large retrospective analysis in Torbay Hospital, unrestricted clear oral fluids until transfer to theatre could significantly reduce the incidence of postoperative nausea and vomiting without an increased risk in the adverse outcomes for which such ...
Typically, the drug is given this way to avoid being stopped by the blood–brain barrier, as it may not be able to pass into the brain when given orally. Drugs given by the intrathecal route often have to be compounded specially by a pharmacist or technician because they cannot contain any preservative or other potentially harmful inactive ...
Oral administration of a liquid. In pharmacology and toxicology, a route of administration is the way by which a drug, fluid, poison, or other substance is taken into the body. [1] Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration ...
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