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[4] [5] [6] DOTB binds with high affinity to the serotonin 5-HT 2 receptors, including to the serotonin 5-HT 2A and 5-HT 2C receptors and, to about a 10-fold lesser extent, to the serotonin 5-HT 2B receptor. [5] [7] [8] [9] It has been assessed and found to act as a partial agonist of the serotonin 5-HT 2B receptor (E max Tooltip maximal ...
In a subsequent publication however, Alexander Shulgin stated that DOSB was inactive at 25 mg orally. [4] David E. Nichols also said that DOSB was inactive at up to 10 mg orally. [9] DOSB was first described in the scientific literature by 1984. [8] [9] Some other notable analogues of DOSB include DOBU (n-butyl), DOIB (iso-butyl), and DOTB (sec ...
Firstly, 2,4-dimethyl-6-tert-butylphenol is reacted with formaldehyde and HCl (Blanc reaction) to generate a chloromethyl group in the less hindered meta position. This intermediate then reacts with cyanuric acid to give the desired product.
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2,5-Dimethoxy-4-butylamphetamine (DOBU) is a lesser-known psychedelic drug and a substituted amphetamine. DOBU was first synthesized by Alexander Shulgin . In his book PiHKAL (Phenethylamines i Have Known And Loved) , only low dosages of 2 to 3 mg were tested, with the duration simply listed as "very long".
NBoc-DMT, or NB-DMT, also known as N1-tert-butoxycarbonyl-N,N-dimethyltryptamine, is a serotonergic psychedelic of the tryptamine family. [ 1 ] [ 2 ] It is a novel designer and recreational drug and is a synthetic modification of dimethyltryptamine (DMT) with an N′ - tert -butyloxycarbonyl (NBoc) group .
Pentaerythritol tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate) is a chemical compound composed of four sterically hindered phenols linked through a pentaerythritol core. It is used as primary antioxidant for stabilizing polymers , particularly polyethylene and polypropylene .
The tissue distribution of probucol has been studied in rats, dogs, and monkeys using a 14 C-labelled version of the drug. In rats, a single 100 mg/kg dose results in liver, adrenal glands, and brown fat concentrations at 3–10× plasma concentration and central nervous system, gonad, and eye concentrations at 1/7–1/20× plasma concentration.