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Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B 3). [2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. [1] Areas of the skin exposed to friction and radiation are typically affected first. [1] Over time affected skin may become darker, stiffen, peel, or bleed. [1] [3]
[4] [5] Niacin as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency. Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness. [6] Many countries mandate its addition to wheat flour or other food grains, thereby reducing the risk of pellagra. [4] [7]
Hartnup disease (also known as "pellagra-like dermatosis" [1] and "Hartnup disorder" [2]) is an autosomal recessive [3] metabolic disorder affecting the absorption of nonpolar amino acids (particularly tryptophan that can be, in turn, converted into serotonin, melatonin, and niacin).
A man with pellagra, which is caused by a chronic lack of vitamin B 3 in the diet. Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. [7]
What is niacin (vitamin B3)? Niacin, a.k.a. vitamin B3, is a water-soluble B vitamin, ... and fortified cereals to lower the risk of developing disease due to nutritional deficiency. It’s also ...
Niacin deficiency, along with a deficiency of tryptophan, causes pellagra. Symptoms include aggression, dermatitis , insomnia , weakness , mental confusion, and diarrhea . In advanced cases, pellagra may lead to dementia and death (the 3(+1) D's: dermatitis, diarrhea, dementia, and death).
“A B12 deficiency can cause physical and neurological symptoms, and research is also growing to support that it can also cause psychological issues as well,” says Shapiro. The list of ...
Some scientific research suggests that vitamin B3, or niacin, may be helpful for managing ED. ... and depression symptoms in young men with low vitamin D status. A meta-analysis from 2020 also ...