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Hippocampal volume is the first imaging biomarker to be qualified, with the help of ADNI data, by the European Medicines Agency to select patients for clinical trials. [42] ADNI also contributed to the development of a standardized technique to manually measure hippocampal volume from MRI scans for use in clinical trials. [43] APOE ε4 allele.
Connectomics is the production and study of connectomes: comprehensive maps of connections within an organism's nervous system.More generally, it can be thought of as the study of neuronal wiring diagrams with a focus on how structural connectivity, individual synapses, cellular morphology, and cellular ultrastructure contribute to the make up of a network.
A connectome (/ k ə ˈ n ɛ k t oʊ m /) is a comprehensive map of neural connections in the brain, and may be thought of as its "wiring diagram". [2] An organism's nervous system is made up of neurons which communicate through synapses. A connectome is constructed by tracing the neuron in a nervous system and mapping where neurons are ...
The first MR images of a human brain were obtained in 1978 by two groups of researchers at EMI Laboratories led by Ian Robert Young and Hugh Clow. [1] In 1986, Charles L. Dumoulin and Howard R. Hart at General Electric developed MR angiography, [2] and Denis Le Bihan obtained the first images and later patented diffusion MRI. [3]
The WU-Minn-Oxford consortium developed improved MRI instrumentation, image acquisition and image analysis methods for mapping the connectivity in the human brain at spatial resolutions significantly better than previously available; using these methods, WU-Minn-Oxford consortium collected a large amount of MRI and behavioral data on 1,200 healthy adults — twin pairs and their siblings from ...
Hippocampal sclerosis (HS) or mesial temporal sclerosis (MTS) is a neuropathological condition with severe neuronal cell loss and gliosis in the hippocampus. [1] Neuroimaging tests such as magnetic resonance imaging (MRI) and positron emission tomography (PET) may identify individuals with hippocampal sclerosis. [2]
Human Connectome Project – 2009 NIH $30 million project to build a network map of the human brain, including structural (anatomical) and functional elements. Emphasis included research into dyslexia, autism, Alzheimer's disease, and schizophrenia. See also Connectome a, comprehensive map of neural connections in the brain.
Since autopsy-like dissection is generally impossible on living brains, brain morphometry starts with noninvasive neuroimaging data, typically obtained from magnetic resonance imaging (MRI). These data are born digital , which allows researchers to analyze the brain images further by using advanced mathematical and statistical methods such as ...