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Gilbert syndrome (GS) is a syndrome in which the liver of affected individuals processes bilirubin more slowly than the majority. [1] Many people never have symptoms. [ 1 ] Occasionally jaundice (a slight yellowish color of the skin or whites of the eyes) may occur.
Gilbert Syndrome, a hereditary disease affecting 5% of the US population, leads to stress-induced mild hyperbilirubinemia. [9] The mutated UGT1 gene produces defective UGT1A1 enzymes vital for bilirubin conjugation.
Crigler-Najjar syndrome is much more severe and presents in newborns. Crigler-Najjar syndrome is the complete or near complete inactivity absence of UGT1A1 activity a more severe unconjugated hyperbilirubinemia compared to Gilbert Syndrome. [2] Dubin-Johnson syndrome and Rotor syndrome cause elevations in conjugated bilirubin. These conditions ...
As the Cleveland Clinic explains, Gilbert's is an inherited condition, but “people with Gilbert's syndrome can lead long, healthy lives. They don’t experience long-term health problems from ...
More rare causes include inherited disorders, such as Dubin–Johnson syndrome and Rotor syndrome. [2] Although Gilbert's syndrome and Crigler–Najjar syndrome are characterized by increased bilirubin in the serum, the bilirubin in these inherited disorders is not conjugated and thus not excreted in the urine.
Joey Graziadei, currently the star of the long-running ABC show, posted a TikTok explaining he has Gilbert syndrome, which is an inherited genetic condition.
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Gilbert's syndrome and Crigler–Najjar syndrome have defects in the UDP-glucuronyl-transferase enzyme, affecting bilirubin conjugation. [6] The degree of rise in conjugated bilirubin is directly proportional to the degree of hepatocyte injury. Viral hepatitis can also cause the rise in conjugated bilirubin.