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Alka-Seltzer is an effervescent antacid and pain reliever owned by Bayer since 1978. First marketed by the Dr. Miles Medicine Company of Elkhart, Indiana , United States , Alka-Seltzer contains three active ingredients: aspirin (acetylsalicylic acid or ASA), sodium bicarbonate , and anhydrous citric acid . [ 1 ]
Calcium carbonate antacid tablets. An antacid is a substance which neutralizes stomach acidity and is used to relieve heartburn, indigestion, or an upset stomach. [1] Some antacids have been used in the treatment of constipation and diarrhea. [2]
The company is known for inventing products such as Alka-Selzer and One-A-Day vitamins. [1] Miles operated as an independent firm from 1884 until 1979 and as a wholly owned subsidiary of Bayer AG from 1979 until 1995. At the company's peak in the 1960s and 1970s, it employed 3,300 people and produced more than two dozen products. [2]
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Extreme bioavailability differences of up to 4-fold have been reported comparing effervescent tablets with ordinary tablets, highlighting the need for extra bioequivalence studies when switching dosage forms. [14] It is dangerous to swallow an effervescent tablet directly, as the tablet can get stuck in the subglottis and fizzle there.
The end of the holiday weekend added two fresh examples of a historic shift on Wall Street: More CEOs than ever are heading for the exits. Over the past 24 hours, the leaders of chipmaker Intel ...