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Ototoxicity is the property of being toxic to the ear (oto-), specifically the cochlea or auditory nerve and sometimes the vestibular system, for example, as a side effect of a drug. The effects of ototoxicity can be reversible and temporary, or irreversible and permanent. It has been recognized since the 19th century. [1]
Very common (>10% incidence) adverse effects include: Somnolence † (produces an intermediate degree of sedation compared to other atypical antipsychotics [4]) Akathisia † Fasting glucose increased † Nausea † Parkinsonism † Insomnia † † These are dose-dependent.
Auditory processing disorder (APD), rarely known as King-Kopetzky syndrome, is a neurodevelopmental disorder affecting the way the brain processes sounds. [2] Individuals with APD usually have normal structure and function of the ear, but cannot process the information they hear in the same way as others do, which leads to difficulties in recognizing and interpreting sounds, especially the ...
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Various ototoxic effects are manifested by using antimalarial drugs, with dizziness being one of the most common one. Other effects include vestibular symptoms, hearing loss and tinnitus, which can appear to be both temporary or permanent. [25] Nonetheless, the underlying mechanisms of antimalarial-induced ototoxicity are still poorly understood.
In conjunction with speech audiometry, it may indicate central auditory processing disorder, or the presence of a schwannoma or other tumor. People with unilateral hearing loss or single-sided deafness (SSD) have difficulty in hearing conversation on their impaired side, localizing sound, and understanding speech in the presence of background ...
Warm the medication if necessary by rolling the medication bottle between the palms. Lay the head on the towel with infected ear facing up. To straighten the ear canal, gently pull the upper ear back and up. Gently shake the medication if instructed. Administer the medication into infected ear.
The effects of aging on central auditory processing abilities are thought to play an important role in impacting an individual's speech perception with a cochlear implant. The Lancet reported that untreated hearing loss in adults is the number one modifiable risk factor for dementia. [ 71 ]