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The term high-functioning autism was used in a manner similar to Asperger syndrome, another outdated classification. The defining characteristic recognized by psychologists was a significant delay in the development of early speech and language skills, before the age of three years. [ 12 ]
In 2013, one study reported that 60% and 44% of 93 children with ASD were positive for FRα-blocking and binding autoantibodies, respectively. This high rate of anti-FRα autoantibody positivity was confirmed by Ramaekers et al. who compared 75 children with ASD to 30 non-autistic "controls".
In 1994, Sally Ozonoff, David L. Strayer, William M. McMahon and Francis Filloux compared information processing skills in high functioning autistics and controls: "The performance of high-functioning autistic children was compared with that of two matched control groups, one with Tourette Syndrome and the other developmentally normal.
Autistic individuals tend to use different brain areas (yellow) for a movement task compared to a control group (blue). [30] The underconnectivity theory of autism posits that autistic people tend to have fewer high-level neural connections and less global synchronization, along with an excess of low-level processes. [31]
Autism spectrum disorder [a] (ASD), or simply autism, is a neurodevelopmental disorder "characterized by persistent deficits in social communication and social interaction across multiple contexts" and "restricted, repetitive patterns of behavior, interests, or activities". [11]
PDD-NOS included atypical autism, a diagnosis defined in the ICD-10 for the case that the criteria for autistic disorder were not met because of late age of onset, or atypical symptomatology, or both of these. [5] Even though PDD-NOS was considered milder than typical autism, this was not always true. While some characteristics may be milder ...
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Regressive autism occurs when a child appears to develop typically but then starts to lose speech and social skills and is subsequently diagnosed with ASD. [15] Other terms used to describe regression in children with autism are autism with regression , autistic regression , setback-type autism , and acquired autistic syndrome .