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Hypertrophic cardiomyopathy (HCM, or HOCM when obstructive) is a condition in which muscle tissues of the heart become thickened without an obvious cause. [8] The parts of the heart most commonly affected are the interventricular septum and the ventricles . [ 10 ]
Hypertrophic cardiomyopathy screening is an assessment and testing to detect hypertrophic cardiomyopathy (HCM). [1] [2]It is a way of identifying HCM in immediate relatives of family members diagnosed with HCM, and athletes as part of a sports medical. [3]
[citation needed] Causes of increased afterload that can cause LVH include aortic stenosis, aortic insufficiency and hypertension. Primary disease of the muscle of the heart that cause LVH are known as hypertrophic cardiomyopathies, which can lead into heart failure. [citation needed]
In dilated cardiomyopathy the ventricles enlarge and weaken. [3] In restrictive cardiomyopathy the ventricle stiffens. [3] In many cases, the cause cannot be determined. [4] Hypertrophic cardiomyopathy is usually inherited, whereas dilated cardiomyopathy is inherited in about one third of cases. [4]
Hypertrophic cardiomyopathy can be a deadly disease, and there was a time when it was largely untreatable. ... “This would involve removing the abnormal piece of genetic material that causes ...
The most common causes of cardiomegaly are congenital (patients are born with the condition based on a genetic inheritance), high blood pressure (which can enlarge the left ventricle causing the heart muscle to weaken over time), and coronary artery disease. In the latter case, the disease creates blockages in the heart's blood supply, leading ...
Additional causes of sudden unexplained cardiac arrest in children include hypertrophic cardiomyopathy and coronary artery abnormalities. [161] In childhood hypertrophic cardiomyopathy, previous adverse cardiac events, non-sustained ventricular tachycardia, syncope, and left ventricular hypertrophy have been shown to predict sudden cardiac ...
[55] [56] MYBPC3 was thus the fourth gene for hypertrophic cardiomyopathy, following MYH7, encoding β-myosin heavy chain, TNNT2 and TPM1, encoding cardiac troponin T and α-tropomyosin, respectively, earmarking hypertrophic cardiomyopathy (HCM) as a disease of the sarcomere. Truncation mutations in MYBPC3 stand as the primary cause of HCM. [57]