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Anti-centromere antibodies are found in approximately 60% of patients with limited systemic scleroderma and in 15% of those with the diffuse form of scleroderma. The specificity of this test is >98%. Thus, a positive anti-centromere antibody finding is strongly suggestive of limited systemic scleroderma.
1059 12616 Ensembl ENSG00000125817 ENSMUSG00000068267 UniProt P07199 P27790 RefSeq (mRNA) NM_001810 NM_007682 RefSeq (protein) NP_001801 NP_031708 Location (UCSC) Chr 20: 3.78 – 3.79 Mb Chr 2: 131.02 – 131.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans ...
Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC conjugate. Anti-SSA autoantibodies (anti–Sjögren's-syndrome-related antigen A autoantibodies, also called anti-Ro, or similar names including anti-SSA/Ro, anti-Ro/SSA, anti–SS-A/Ro, and anti-Ro/SS-A) are a type of anti-nuclear autoantibodies that are associated with ...
Blood type (also called a blood group) is a classification of blood, based on the presence and absence of antibodies and inherited antigenic substances on the surface of red blood cells (RBCs). These antigens may be proteins, carbohydrates, glycoproteins, or glycolipids, depending on the blood group system.
HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen.DQ8 is determined by the antibody recognition of β 8 and this generally detects the gene product of DQB1*0302.
In a comparative study (in 2007), various detection kits had a sensitivity between 69.6% and 77.5% and a specificity between 87.8% and 96.4%. [12] Despite the excellent performance of these immunoassays, for example CCP-assays, they only provide a sensitivity comparable with that of rheumatoid factor (RF).
The true positive in this figure is 6, and false negatives of 0 (because all positive condition is correctly predicted as positive). Therefore, the sensitivity is 100% (from 6 / (6 + 0) ). This situation is also illustrated in the previous figure where the dotted line is at position A (the left-hand side is predicted as negative by the model ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 23 December 2024. DNA molecule containing genetic material of a cell This article is about the DNA molecule. For the genetic algorithm, see Chromosome (genetic algorithm). Chromosome (10 7 - 10 10 bp) DNA Gene (10 3 - 10 6 bp) Function A chromosome and its packaged long strand of DNA unraveled. The DNA's ...