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  2. Dapagliflozin/metformin - Wikipedia

    en.wikipedia.org/wiki/Dapagliflozin/metformin

    [4] [5] It is a combination of dapagliflozin and metformin [4] and is taken by mouth. [4] Dapagliflozin/metformin was approved for use in the European Union in January 2014, [ 3 ] in the United States in February 2014, [ 5 ] [ 6 ] and in Australia in July 2014.

  3. Metformin - Wikipedia

    en.wikipedia.org/wiki/Metformin

    The US FDA granted the application for metformin orphan drug designation. [166] ... [197] [198] a saxagliptin/metformin combination (Kombiglyze XR, Komboglyze), ...

  4. Dapagliflozin - Wikipedia

    en.wikipedia.org/wiki/Dapagliflozin

    The combination drug was approved for medical use in the United States in February 2017, where it also is sold under the brand name Qtern. [ 59 ] [ 60 ] In May 2019, the fixed-dose combination of dapagliflozin, saxagliptin, and metformin hydrochloride as extended-release tablets was approved in the United States to improve glycemic control in ...

  5. SGLT2 inhibitor - Wikipedia

    en.wikipedia.org/wiki/SGLT2_inhibitor

    Sotagliflozin (Inpefa) is a dual SGLT1/SGLT2 inhibitor approved by the US Food and Drug Administration (FDA) in May 2023, to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with heart failure or type 2 diabetes, chronic kidney disease, and other cardiovascular risk factors.

  6. Sitagliptin - Wikipedia

    en.wikipedia.org/wiki/Sitagliptin

    In December 2020, the US Food and Drug Administration (FDA) approved labeling changes stating that Januvia (sitagliptin), Janumet (sitagliptin and metformin hydrochloride), and Janumet XR (sitagliptin and metformin hydrochloride extended-release) are not proven to improve glycemic (blood sugar) control in children aged 10 to 17 with type 2 ...

  7. Modified-release dosage - Wikipedia

    en.wikipedia.org/wiki/Modified-release_dosage

    Modified-release dosage. Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]

  8. Empagliflozin/metformin - Wikipedia

    en.wikipedia.org/wiki/Empagliflozin/metformin

    Empagliflozin/metformin was approved for use in the European Union in May 2015. [5] Empagliflozin/metformin was approved for use in the United States in August 2015. [6] [11] The extended release version was approved for use in the United States in December 2016. [12] [13] Empagliflozin/metformin was approved for use in Australia in May 2020. [2]

  9. Empagliflozin/linagliptin/metformin - Wikipedia

    en.wikipedia.org/.../linagliptin/metformin

    To reduce the risk of developing ketoacidosis (a serious condition where the body produces high levels of blood acids called ketones) after surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medications, recommending they be temporarily stopped before scheduled surgery.

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