Search results
Results from the WOW.Com Content Network
This file contains additional information, probably added from the digital camera or scanner used to create or digitize it. If the file has been modified from its original state, some details may not fully reflect the modified file.
DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity for A 2 adenosine receptors, in contrast to the A 1 subtype receptors. [1] DMPX had 28 times and 15 times higher potency than caffeine in blocking, respectively, the peripheral and central effects of the adenosine agonist NECA.
This suggests that its antiasthmatic effects are mediated by another mechanism, perhaps its actions on phosphodiesterase. [1] From a pharmacokinetic point of view, doxofylline importantly differs from theophylline also because it lacks the ability to interfere with the cytochrome enzymes CYP1A2 , CYP2E1 and CYP3A4 , thus preventing significant ...
Antibiotics by class Generic name Brand names Common uses [4] Possible side effects [4] Mechanism of action Aminoglycosides; Amikacin: Amikin: Infections caused by Gram-negative bacteria, such as Escherichia coli and Klebsiella particularly Pseudomonas aeruginosa. Effective against aerobic bacteria (not obligate/facultative anaerobes) and ...
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.
Adverse effects are uncommon and include skin rashes, pruritus (itching), erythema, angioedema, breathing problems such as dyspnea and asthma, anaphylaxis (serious allergic reactions), and decrease in the number of blood cells such as thrombocytopenia, leucopenia, agranulocytosis, and pancytopenia. [2] The latter type of side effect can be ...
The wakefulness-promoting effects of non-selective adenosine receptor antagonists like caffeine appear to be mediated specifically and exclusively by antagonism of the adenosine A 2A receptor. [ 12 ] [ 13 ] There is preliminary clinical evidence that istradefylline has wakefulness-promoting effects similarly to caffeine.
The name lantibiotics was introduced in 1988 as an abbreviation for "lanthionine-containing peptide antibiotics". [1] The first structures of these antimicrobial agents were produced by pioneering work by Gross and Morell in the late 1960s and early 1970s, thus marking the formal introduction of lantibiotics.