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Autism is associated with several genetic disorders, [4] perhaps due to an overlap in genetic causes. [5] About 10–15% of autism cases have an identifiable Mendelian (single-gene) condition, chromosome abnormality, or other genetic syndrome, [6] a category referred to as syndromic autism.
Crohn's disease: "We report three cases of young 18 to 25 year-old girls, initially treated for anorexia nervosa in a psychiatric department. Diagnosis of Crohn's disease was made within 5 to 13 years."(Blanchet C, Luton JP. 2002)"This disease should be diagnostically excluded before accepting anorexia nervosa as final diagnosis".
Which autism spectrum diagnoses can be made and which criteria are used depends on the local healthcare system's regulations. According to the DSM-5-TR (2022), in order to receive a diagnosis of autism spectrum disorder, one must present with "persistent deficits in social communication and social interaction" and "restricted, repetitive ...
The development of autism is associated with several prenatal risk factors, including advanced age in either parent, diabetes, bleeding, and maternal use of antibiotics and psychiatric drugs during pregnancy. [1] [52] [53] Autism has been linked to birth defect agents acting during the first eight weeks from conception, though these cases are ...
Rett syndrome brain samples and autism brain samples show immaturity of dendrite spines and reduction of cell-body size due to errors in coupled regulation between MECP2 and EGR2. [62] However, because of the multigene involvement in autism, the MECP2 gene has only been identified as a vulnerability factor in autism. [63]
The association between inflammatory conditions of the eye and Crohn's disease is due to many Crohn's disease patients having genetic markers such as HLA-B07, HLA-B27 and HLA-DRB1*0103. [57] Additionally, cytokines IL-6, IL-10, and IL-17 which are produced in the bowel enter the circulatory system and travel to the eyes to trigger inflammation.
ASD averages a 4.3:1 male-to-female ratio. The number of children diagnosed with the autism spectrum has increased dramatically since the 1980s, at least partly due to changes in diagnostic practice; it is unclear whether prevalence has actually increased; [3] and as-yet-unidentified environmental risk factors cannot be ruled out. [4]
Bile acid malabsorption is common in Crohn's disease but not always recognized. Most people with previous ileal resection and chronic diarrhea will have abnormal SeHCAT tests and can benefit from bile acid sequestrants. [4] People with primary bile acid diarrhea are frequently misdiagnosed as having irritable bowel syndrome. [17]