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In osteoarthritis, joint injection of glucocorticoids (such as hydrocortisone) leads to short term pain relief that may last between a few weeks and a few months. [5] Injections of hyaluronic acid have not produced improvement compared to placebo for knee arthritis, [6] [7] but did increase risk of further pain. [6]
Sodium hyaluronate has a very low incidence of side effects, however it is contraindicated in people who are sensitive to hyaluronate preparations. If being administered as an intra-articular injection, it should not be given when there are infections or skin disease at the injection site. [24] [25]
Patients receiving prolotherapy injections have reported generally mild side effects, including mild pain and irritation at the injection site [20] [21] (often within 72 hours of the injection), numbness at the injection site, or mild bleeding.
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After an image of Karl-Anthony Towns wearing a knee brace surfaced over the weekend, ESPN's Ramona Shelburne reported on Sunday that he underwent treatment in both knees and other parts of his body.
A 2020 meta-analysis found that intra-articular injection of high molecular weight HA improved both pain and function in people with knee osteoarthritis. [27] Hyaluronic acid has been used to treat dry eye. [28] Hyaluronic acid is a common ingredient in skin care products. Hyaluronic acid is used as a dermal filler in cosmetic surgery. [29]
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