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Neutron capture therapy is a binary system that consists of two separate components to achieve its therapeutic effect. Each component in itself is non-tumoricidal, but when combined they can be highly lethal to cancer cells. 1) Boron compound (b) is selectively absorbed by cancer cell(s). 2) Neutron beam (n) is aimed at cancer site.
Neutron capture therapy was first proposed in the literature in 1936 by Gordon L. Locher, who observed that isotopes with large neutron capture cross sections, such as boron-10, could be accumulated in cancerous tissue and bombarded with thermal neutrons to induce destruction of the cancerous cells. [4]
No cancer therapy is without the risk of side effects. Neutron therapy is a very powerful nuclear scalpel that has to be utilized with exquisite care. For instance, some of the most remarkable cures it has been able to achieve are with cancers of the head and neck. Many of these cancers cannot effectively be treated with other therapies.
Fast neutron therapy utilizes high energy neutrons typically between 50 and 70 MeV to treat cancer. Most fast neutron therapy beams are produced by reactors, cyclotrons (d+Be) and linear accelerators. Neutron therapy is currently available in Germany, Russia, South Africa and the United States.
Selected tissue distribution studies on one of these nanotubes, {([Na+][1-Me-2-((CH2)4NH-)-1,2-C2B9H10][OEt])n(SWCNT)} (Va), showed that the boron atoms are concentrated more in tumors cells than in blood and other organs, making it an attractive nanovehicle for the delivery of boron to tumor cells for an effective boron neutron capture therapy ...
Similar to its porphyrin analogues, TPz molecules have potential as drugs for PDT cancer treatments. For example, researchers reported a TPz derivative as a promising PDT/BNCT ( boron neutron capture therapy ) candidate, in which TPz molecule with pyridyl substituents, where the nitrogen atoms of the latter were coordinated to a palladium ...
Each salient feature of the reactor was designed in relation to its use for therapy and diagnosis or in the advancement of basic medical science.” [3] One of the treatments pioneered at this reactor was boron neutron capture therapy, or BNCT. This promising treatment was developed for use against glioblastoma multiforme, an otherwise ...
Neutron capture therapy of cancer#Boron neutron capture therapy; Retrieved from "https: ...
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