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Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, [1] seen in diseases such as pemphigus vulgaris. [2] It is absent in bullous pemphigoid , making it useful for differential diagnosis .
Variable degree of epidermal spongiosis and vesicle formation, filled with proteinaceous fluid containing lymphocytes and histiocytes. Usually superficial dermal edema with perivascular lymphocytic infiltrate, with exocytosis. No acanthosis or parakeratosis. Typical findings: [2] Mild to moderate spongiosis and exocytosis of inflammatory cells
Histopathological image of dyshidrotic dermatitis, showing focal spongiotic change in the epidermis. Spongiosis is mainly intercellular [1] edema (abnormal accumulation of fluid) in the epidermis, [2] and is characteristic of eczematous dermatitis, manifested clinically by intraepidermal vesicles (fluid-containing spaces), "juicy" papules, and/or lichenification. [3]
Hand eczema is widely prevalent and, as it is a very visible condition associated with severe itching or pain, has serious consequences for the affected person including a high psychological impact. Different disease patterns can be identified according to the course of the illness, appearance of symptoms, degree of severity, or catalysts.
Note the intercellular IgG deposits in the epidermis and the early intraepidermal vesicle caused by acantholysis. Pemphigus (/ ˈ p ɛ m f ɪ ɡ ə s / or / p ɛ m ˈ f aɪ ɡ ə s /) is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. [1] The name is derived from the Greek root pemphix, meaning "blister ...
Early actinic keratosis with parakeratosis, with black arrows indicating one of multiple retained nuclei in the stratum corneum. Parakeratosis is a mode of keratinization characterized by the retention of nuclei in the stratum corneum. [1]
Pathology image of lymphocytic esophagitis (H&E stain). The image demonstrates common findings in the condition: dense peripapillary lymphocytic infiltrate with spongiosis (arrow), and absence of neutrophils and eosinophils. Specialty: Gastroenterology: Symptoms: difficulty swallowing, heartburn, abdominal pain, food bolus obstruction ...
A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. [1]