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Dabigatran, sold under the brand name Pradaxa among others, is an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. [ 6 ] [ 7 ] Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots. [ 6 ]
Researchers analyzed the weights of more than 183,000 adult antidepressant users six months, a year and two years after they started taking the drugs.
In addition, about 15–30% of participants had weight measurements exactly at the 6-month, 1-year, and 2-year marks, and only 40% to 50% had weight measurements at one time point or more. This ...
Dabigatran is an oral direct thrombin inhibitor. Dabigatran (Pradaxa) was found to be noninferior to Warfarin in prevention of ischemic stroke, as well as intracranial hemorrhage risk and overall mortality for non-valvular atrial fibrillation according to the RE-LY trial.
Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood thinners in use. People admitted to hospital requiring blood thinning were started on an infusion of heparin infusion, which thinned blood ...
Over the years, several studies and meta-analyses have found that people who use bupropion to treat depression tend to gain less weight than their peers, with some people prescribed this ...
The PF4-heparin complex can activate platelets and may cause venous and arterial thrombosis. [8] When lepirudin binds to thrombin it hinders its prothrombic activity. [ 16 ] Three prospective studies , called the Heparin-Associated-Thrombocytopenia (HAT) 1,2, and 3, were performed that compared lepirudin with historical controls in the ...
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