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Methocarbamol is a centrally acting skeletal muscle relaxant that has significant potential adverse effects, especially on the central nervous system. [3] Potential side effects of methocarbamol include: Most commonly drowsiness, blurred vision, headache, nausea, and skin rash. [8]
Other common spasmolytic agents include: methocarbamol, carisoprodol, chlorzoxazone, cyclobenzaprine, gabapentin, metaxalone, and orphenadrine. Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects and an unknown mechanism of action.
[medical citation needed] Both of these drugs have side effects common to anticholinergics and can worsen gastroesophageal reflux disease (GERD). [2] Papaverine is an opium alkaloid used to treat visceral spasms, particularly those of the intestines. [3]
Oliceridine is a μ-opioid receptor biased agonist developed by Trevena.In cell-based (in vitro) research, oliceridine elicits robust G protein signaling, with potency and efficacy similar to that of morphine, but with less β-arrestin 2 recruitment and receptor internalization. [5]
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Nausea is one of the most frequently reported side effects when starting a GLP-1 medication, due to slowed-down digestion. Nausea may be related to overeating while taking these medications as well.
Meprobamate—marketed as Miltown by Wallace Laboratories and Equanil by Wyeth, among others—is a carbamate derivative used as an anxiolytic drug. It was the best-selling minor tranquilizer for a time, but has largely been replaced by the benzodiazepines due to their wider therapeutic index (lower risk of toxicity at therapeutically prescribed doses) and lower incidence of serious side effects.
Eperisone (formulated as the eperisone hydrochloride salt) is an antispasmodic drug.. Eperisone acts by relaxing both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex.