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  2. Primary aldosteronism - Wikipedia

    en.wikipedia.org/wiki/Primary_aldosteronism

    Primary aldosteronism. Primary aldosteronism (PA), also known as primary hyperaldosteronism, refers to the excess production of the hormone aldosterone from the adrenal glands, resulting in low renin levels and high blood pressure. [1] This abnormality is a paraneoplastic syndrome (i.e. caused by hyperplasia or tumors).

  3. Aldosterone - Wikipedia

    en.wikipedia.org/wiki/Aldosterone

    When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and kidney disease. [8] Aldosterone has exactly the opposite function of the atrial natriuretic hormone secreted by the heart. [7] Aldosterone is part of the renin–angiotensin–aldosterone system.

  4. Liddle's syndrome - Wikipedia

    en.wikipedia.org/wiki/Liddle's_syndrome

    Liddle's syndrome, also called Liddle syndrome, [1] is a genetic disorder inherited in an autosomal dominant manner that is characterized by early, and frequently severe, high blood pressure associated with low plasma renin activity, metabolic alkalosis, low blood potassium, and normal to low levels of aldosterone. [1] Liddle syndrome involves abnormal kidney function, with excess reabsorption ...

  5. Adrenal insufficiency - Wikipedia

    en.wikipedia.org/wiki/Adrenal_insufficiency

    In adrenal insufficiency, there is a deficiency in cortisol production which may be accompanied by a deficiency in aldosterone production (predominantly in primary adrenal insufficiency). [2][3] Depending on the cause and type of adrenal insufficiency, the mechanism of the disease differs.

  6. Renin–angiotensin system - Wikipedia

    en.wikipedia.org/wiki/Renin–angiotensin_system

    Renin–angiotensin system. The renin-angiotensin system (RAS), or renin-angiotensin-aldosterone system (RAAS), is a hormone system that regulates blood pressure, fluid, and electrolyte balance, and systemic vascular resistance. [2][3] When renal blood flow is reduced, juxtaglomerular cells in the kidneys convert the precursor prorenin (already ...

  7. Pseudohypoaldosteronism - Wikipedia

    en.wikipedia.org/wiki/Pseudohypoaldosteronism

    PHA1 is an heterogeneous disease, which can be caused by mutations in different genes. On one hand, mutations on the gene NR3C2 (coding the mineralocorticoid receptor) cause the synthesis of a non-functional receptor which is unable to bind aldosterone or function correctly. In the kidney, aldosterone plays an important role of regulating sodium and potassium homeostasis by its actions on ...

  8. Distal renal tubular acidosis - Wikipedia

    en.wikipedia.org/wiki/Distal_renal_tubular_acidosis

    Aldosterone causes increased resorption of sodium and loss of potassium in the collecting duct of the kidney, so these increased aldosterone levels cause the hypokalemia which is a common symptom of dRTA.

  9. Addison's disease - Wikipedia

    en.wikipedia.org/wiki/Addison's_disease

    Addison's disease, also known as primary adrenal insufficiency, [4] is a rare long-term endocrine disorder characterized by inadequate production of the steroid hormones cortisol and aldosterone by the two outer layers of the cells of the adrenal glands (adrenal cortex), causing adrenal insufficiency. [5][6] Symptoms generally come on slowly ...

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