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Styrene oxide is a main metabolite of styrene in humans or animals, resulting from oxidation by cytochrome P450. It is considered possibly carcinogenic from gavaging significant amounts into mice and rats. [4] Styrene oxide is subsequently hydrolyzed in vivo to styrene glycol by epoxide hydrolase. [5]
Styrene is regarded as a "known carcinogen", especially in case of eye contact, but also in case of skin contact, of ingestion and of inhalation, according to several sources. [20] [33] [34] [35] Styrene is largely metabolized into styrene oxide in humans, resulting from oxidation by cytochrome P450.
Styrene is "generally found in such low levels in consumer products that risks aren't substantial". [110] Polystyrene which is used for food contact may not contain more than 1% (0.5% for fatty foods) of styrene by weight. [111] Styrene oligomers in polystyrene containers used for food packaging have been found to migrate into the food. [112]
Residents near Cleves are being urged to leave their homes Tuesday afternoon because a rail car is leaking styrene. What to know about the chemical.
Here's what the Drug & Poison Information Center at Cincinnati Children’s Hospital advises regarding returning home following the styrene leak.
as the first step of the aerobic styrene degradation pathway. [1] The product 2-phenyloxirane is also known as styrene oxide and can be converted by a styrene oxide isomerase (SOI) to obtain phenylacetaldehyde, which can be transformed into the key-intermediate phenylacetic acid by a phenylacetaldehyde dehydrogenase (PAD).
Styrene is a flammable gas and can be fatal if inhaled. The chemical is also considered a probable human carcinogen that can damage organs, inflame lungs, and make it hard to breathe, according to ...
Illustrative is the epoxidation of styrene with perbenzoic acid to styrene oxide: [12] The stereochemistry of the reaction is quite sensitive. Depending on the mechanism of the reaction and the geometry of the alkene starting material, cis and/or trans epoxide diastereomers may be formed. In addition, if there are other stereocenters present in ...