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Mitosis is preceded by the S phase of interphase (during which DNA replication occurs) and is followed by telophase and cytokinesis, which divide the cytoplasm, organelles, and cell membrane of one cell into two new cells containing roughly equal shares of these cellular components. [2]
G 2 phase occurs after DNA replication and is a period of protein synthesis and rapid cell growth to prepare the cell for mitosis. During this phase microtubules begin to reorganize to form a spindle (preprophase). Before proceeding to mitotic phase, cells must be checked at the G 2 checkpoint for any DNA damage within the chromosomes.
Curiously, G 2 phase is not a necessary part of the cell cycle, as some cell types (particularly young Xenopus embryos [1] and some cancers [2]) proceed directly from DNA replication to mitosis. Though much is known about the genetic network which regulates G2 phase and subsequent entry into mitosis, there is still much to be discovered ...
Note: Cytoplasm of this cell or the neighboring cell is not visible (top-left), which is currently in the telophase of mitosis. Image taken using an optical microscope and DAPI staining of DNA. Interphase is the active portion of the cell cycle that includes the G1 , S , and G2 phases, where the cell grows , replicates its DNA , and prepares ...
Interphase is the process through which a cell must go before mitosis, meiosis, and cytokinesis. [15] Interphase consists of three main phases: G 1, S, and G 2. G 1 is a time of growth for the cell where specialized cellular functions occur in order to prepare the cell for DNA replication. [16]
Replication timing is correlated with the expression of genes such that the genetic information being utilized in a cell is generally replicated earlier than the information that is not being used. We also know that the replication-timing program changes during development, along with changes in the expression of genes.
After G1, the cells enter S phase during which the DNA is replicated. After S, the cell will enter G2 where the proteins required for mitosis to occur are synthesized. Unlike most cell types however, neurons are generally considered incapable of proliferating once they are differentiated, as they are in the adult nervous system. Nevertheless ...
In eukaryotes, the vast majority of DNA synthesis occurs during S phase of the cell cycle, and the entire genome must be unwound and duplicated to form two daughter copies. During G 2, any damaged DNA or replication errors are corrected. Finally, one copy of the genomes is segregated into each daughter cell at the mitosis or M phase. [2]