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Substance use is also often associated with premature ageing, fertility complications, brain damage and a higher risk of infectious diseases due to a weakened immune system. [15] [16] Long-term use has been linked to personality changes such as depression, paranoia, anxiety which can be related to psychological disorders.
Legal cannabis (marijuana) product. Overconsumption and reliance could lead to cannabis-induced amotivational syndrome. The term amotivational syndrome was first devised to understand and explain the diminished drive and desire to work or compete among the population of youth who are frequent consumers of cannabis and has since been researched through various methodological studies with this ...
Cannabis hyperemesis syndrome causes regular cannabis users to vomit, and the only way to stop the condition is to cease weed use. Vaping-related lung damage and psychosis are also reported, yet ...
Cannabinoid hyperemesis syndrome (CHS) is recurrent nausea, vomiting, and cramping abdominal pain that can occur due to prolonged, high-dose cannabis use. [4] [5] CHS is associated with frequent (weekly or more often), long-term (several months or longer) cannabis use; synthetic cannabinoids can also cause CHS.
Research has shown that excessive alcohol use causes an 8-fold increased risk of psychotic disorders in men and a 3 fold increased risk of psychotic disorders in women. [ 11 ] [ 12 ] While the vast majority of cases are acute and resolve fairly quickly upon treatment and/or abstinence, they can occasionally become chronic and persistent. [ 8 ]
People sometimes use cannabis to cope with their anxiety, and cannabis withdrawal can lead to symptoms of anxiety. [58] Buspirone, a serotonin 5-HT 1A receptor partial agonist, has shown limited efficacy for treating anxiety in people with cannabis use disorder, though there may be better efficacy in males than in females. [58]
Failure to manage the alcohol withdrawal syndrome appropriately can lead to permanent brain damage or death. [ 11 ] Acamprosate , a drug used to promote abstinence from alcohol, an NMDA antagonist drug, reduces excessive glutamate activity in the central nervous system and thereby may reduce excitotoxicity and withdrawal related brain damage.
Intoxication from both alcohol and cannabis is known as being cross faded, although the term is also used less commonly for combinations of other substances. [ 15 ] The spins are often reported when alcohol is mixed with cannabis, since both may cause dizziness [ 2 ] and magnify each other's effects. [ 16 ]