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Diagram showing the development of different blood cells from haematopoietic stem cell to mature cells Comprehensive diagram that shows the development of different blood cells from haematopoietic stem cell to mature cells in both myeloid and lymphoid lineages.
A metamyelocyte is a cell undergoing granulopoiesis, derived from a myelocyte, and leading to a band cell. It is characterized by the appearance of a bent nucleus, cytoplasmic granules, and the absence of visible nucleoli. (If the nucleus is not yet bent, then it is likely a myelocyte.)
A myelocyte is a young cell of the granulocytic series, occurring normally in bone marrow (can be found in circulating blood when caused by certain diseases). Structure [ edit ]
The development of granules continues with the next stage, a myelocyte. At this point, the nucleus is starting to shrink. At this point, the nucleus is starting to shrink. At the stage of a metamyelocyte the cell nucleus is becoming kidney-shaped and it becomes even more bent in the stage of a band cell .
In hematology, myelopoiesis in the broadest sense of the term is the production of bone marrow and of all cells that arise from it, namely, all blood cells. [1] In a narrower sense, myelopoiesis also refers specifically to the regulated formation of myeloid leukocytes (), including eosinophilic granulocytes, basophilic granulocytes, neutrophilic granulocytes, and monocytes.
Conventionally, a leukocytosis exceeding 50,000 WBC/mm 3 with a significant increase in early neutrophil precursors is referred to as a leukemoid reaction. [2] The peripheral blood smear may show myelocytes, metamyelocytes, promyelocytes, and rarely myeloblasts; however, there is a mixture of early mature neutrophil precursors, in contrast to the immature forms typically seen in acute leukemia.
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A comprehensive diagram of human hematopoiesis. Granulopoiesis consists of 5 stages, in which the myeloblast is the first recognizable cell. Next in the differentiation sequence is the monoblast and the promyelocyte, which can develop into one of three different precursor cells: the neutrophilic, basophilic or eosinophilic myelocyte.