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Methanesulfonyl chloride is mainly used to give methanesulfonates by its reaction with alcohols in the presence of a non-nucleophilic base. [8] In contrast to the formation of toluenesulfonates from alcohols and p-toluenesulfonyl chloride in the presence of pyridine, the formation of methanesulfonates is believed to proceed via a mechanism wherein methanesulfonyl chloride first undergoes an ...
Passage of hydrogen chloride through molten Ms 2 O yields MsCl. [3] Similar to MsCl, Ms 2 O can perform mesylation of alcohols to form sulfonates. Use of Ms 2 O avoids the alkyl chloride, which often appears as a side-product when MsCl is used. [4] Unlike MsCl, Ms 2 O may not be suitable for mesylation of the unsaturated alcohols. [5]
The discovery stemmed from earlier work by Berzelius and Marcet in 1813, who treated carbon disulfide with moist chlorine and produced a compound they named "sulphite of chloride of carbon". By reacting it with barium hydroxide Kolbe demonstrated it to actually be trichloromethylsulfonyl chloride (CCl₃SO₂Cl in modern notation).
Methanesulfonyl chloride is often referred to as mesyl chloride. Whereas mesylates are often hydrolytically labile, mesyl groups, when attached to nitrogen , are resistant to hydrolysis. [ 5 ] This functional group appears in a variety of medications, particularly cardiac ( antiarrhythmic ) drugs, as a sulfonamide moiety.
Methanesulfonyl chloride; Methyl azide; Methyl isocyanate; Methyl isocyanide; Methyl phenyl sulfoxide; N-Methyl-2-pyrrolidone; 9-Methyl-β-carboline; N-Methylacetamide;
Tosyl chloride (p-toluenesulfonyl chloride) CH 3 C 6 H 4 SO 2 Cl Brosyl: p-bromobenzenesulfonyl Bs Nosyl o- or p-nitrobenzenesulfonyl Ns Mesyl: methanesulfonyl Ms Mesyl chloride (methanesulfonyl chloride) CH 3 SO 2 Cl Triflyl: trifluoromethanesulfonyl Tf Tresyl: 2,2,2-trifluoroethyl-1-sulfonyl Dansyl: 5-(dimethylamino)naphthalene-1-sulfonyl Ds ...
Methanesulfonyl fluoride (MSF) has long been known to be a potent inhibitor of acetylcholinesterase (AChE), the enzyme that regulates acetylcholine, an important neurotransmitter in both the central and peripheral nervous systems.
Methanesulfonyl chloride; Methanesulfonyl fluoride; P. ... PMSF; T. 4-Toluenesulfonyl chloride This page was last edited on 3 July 2017, at 23:46 (UTC). ...