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The N-terminal acts as an allosteric regulator of C-terminal; the C-terminal is the only one involved in the catalytic activity. HK-I is regulated by the concentration of G6P, where G6P acts as a feedback inhibitor. At low G6P concentration, HK-I is activated; at high G6P concentration, the HK-I is inhibited. [1]
This domain can bind phosphatidylinositol lipids within biological membranes (such as phosphatidylinositol (3,4,5)-trisphosphate and phosphatidylinositol (4,5)-bisphosphate), [8] and proteins such as the βγ-subunits of heterotrimeric G proteins, [9] and protein kinase C. [10]
[1] [2] CRP then activates transcription through direct protein–protein interactions with RNA polymerase. [1] [2] The genes regulated by CRP are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system. [3] [4] In Escherichia coli, CRP can regulate the transcription of more than 100 genes. [5]
For radiolabeling, the pH of the 68 Ga containing generator eluate has to be raised from its initial value (depending on HCl concentration, pH 1–1.5) to pH 2–3.5 [11] using suitable buffers, such as sodium acetate.
On the category of oxidative addition, M. L. H. Green in 1970 reported on the photochemical insertion of tungsten (as a Cp 2 WH 2 complex) in a benzene C–H bond [7] and George M. Whitesides in 1979 was the first to carry out an intramolecular aliphatic C–H activation [8] Fujiwara's palladium- and copper-catalyzed C-H functionalization
The property of the GAL1-GAL10 to bind the GAL4 protein is utilised in the GAL4/UAS technique for controlled gene mis-expression in Drosophila. This is the most popular form of binary expression in Drosophila melanogaster, a system which has been adapted for many uses to make Drosophila melanogaster one of the most genetically tractable multicellular organisms. [5]
PPAR-α is primarily activated through ligand binding. Endogenous ligands include fatty acids such as arachidonic acid as well as other polyunsaturated fatty acids and various fatty acid-derived compounds such as certain members of the 15-hydroxyeicosatetraenoic acid family of arachidonic acid metabolites, e.g. 15(S)-HETE, 15(R)-HETE, and 15(S)-HpETE and 13-hydroxyoctadecadienoic acid, a ...
Tetraacetylethylenediamine, commonly abbreviated as TAED, is an organic compound with the formula (CH 3 C(O)) 2 NCH 2 CH 2 N(C(O)CH 3) 2. It is a white solid commonly used as a bleach activator in laundry detergents and in the production of paper pulp. TAED is synthesized through the acetylation of ethylenediamine.