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As the cotransport of glucose with sodium from the lumen does not directly require ATP hydrolysis but depends upon the action of the ATPase, this is described as secondary active transport. [ 10 ] There are two types of secondary active transporter found within the kidney tubule; close to the glomerulus , where glucose levels are high, SGLT2 ...
The transport of glucose across the proximal tubule cell membrane involves a complex process of secondary active transport (also known as co-transport). [3] This process begins with the Na + /K + ATPase on the basolateral membrane. This enzyme uses ATP to pump 3 sodium ions out of the cell into the blood while bringing 2 potassium ions into the ...
The Na–K–Cl cotransporter (NKCC) is a transport protein that aids in the secondary active transport of sodium, potassium, and chloride into cells. [1] In humans there are two isoforms of this membrane transport protein, NKCC1 and NKCC2, encoded by two different genes (SLC12A2 and SLC12A1 respectively). Two isoforms of the NKCC1/Slc12a2 gene ...
Cotransporters are a subcategory of membrane transport proteins (transporters) that couple the favorable movement of one molecule with its concentration gradient and unfavorable movement of another molecule against its concentration gradient. They enable coupled or cotransport (secondary active transport) and include antiporters and symporters.
The sodium-chloride symporter or NCC is a member of the SLC12 cotransporter family of electroneutral cation-coupled chloride cotransporter, along with the potassium-chloride cotransporters (K +-Cl − cotransporters or KCCs), the sodium-potassium-chloride cotransporters (Na +-K +-Cl − cotransporters or NKCCs) and orphan member CIP (cotransporter interacting protein) and CCC9.
A comparison of transport proteins [1]. An antiporter (also called exchanger or counter-transporter) is an integral membrane protein that uses secondary active transport to move two or more molecules in opposite directions across a phospholipid membrane.
However, glucose, amino acids, inorganic phosphate, and some other solutes are reabsorbed via secondary active transport through cotransport channels driven by the sodium gradient. Renin–angiotensin system: The kidneys sense low blood pressure. Release renin into the blood. Renin causes production of angiotensin I.
Sodium (Na +), potassium (K +) and chloride (Cl −) ions are reabsorbed from the urine by secondary active transport by a Na–K–Cl cotransporter (NKCC2). The electrical and concentration gradient drives more reabsorption of Na +, as well as other cations such as magnesium (Mg 2+) and calcium (Ca 2+). Cortical thick ascending limb