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The scarring of the small blood vessels, called capillary sclerosis, is the initial lesion of analgesic nephropathy. [7] Found in the renal pelvis, ureter, and capillaries supplying the nephrons, capillary sclerosis is thought to lead to renal papillary necrosis and, in turn, chronic interstitial nephritis.
Elevated liver enzymes; Hepatitis (liver swelling) Stomatitis (mouth swelling) Liver failure; Pulmonary oedema (fluid in the lungs) Gastrointestinal bleeding; Pulmonary embolism; Myocardial ischaemia (lack of blood supply to the heart muscles) Speech disorders; Haemoglobin decrease; Proteinuria (protein in the urine; usually indicative of ...
Common side effects include heartburn, nausea, indigestion, and abdominal pain. [8] As with other NSAIDs, potential side effects include gastrointestinal bleeding. [10] Long-term use has been associated with kidney failure, and rarely liver failure, and it can exacerbate the condition of patients with heart failure. [8]
NSAIDs are also associated with a fairly high incidence of adverse drug reactions on the kidney and over time can lead to chronic kidney disease. The mechanism of these kidney ADRs is due to changes in kidney blood flow. Prostaglandins normally dilate the afferent arterioles of the glomeruli.
If you have underlying liver damage, consult your healthcare provider or pharmacist before taking Tylenol — either it should be taken sparingly, or avoided altogether, adds Mangan.
Type A: augmented pharmacological effects, which are dose-dependent and predictable [5]; Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g., bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g., nausea from digoxin), and they are therefore predictable.
These are called "simple" drug eruptions. However, more serious drug eruptions may be associated with organ injury such as liver or kidney damage and are categorized as "complex". [2] Drugs can also cause hair and nail changes, affect the mucous membranes, or cause itching without outward skin changes. [3]
This is due to a depressed excretion via the kidneys causing a buildup of the medication in the skin, and normally indicates a need to discontinue usage. [4] Other such side effects include fever, confusion, shortness of breath, skin rash, and swelling of the face, fingers, feet, or legs. [3] [4] Long-term use may cause yellowing of nails. [7]
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