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Hypertrophic osteoarthropathy is a medical condition combining clubbing and periostitis of the small hand joints, especially the distal interphalangeal joints and the metacarpophalangeal joints. Distal expansion of the long bones as well as painful, swollen joints [ 3 ] and synovial villous proliferation are often seen.
Other names are primary hypertrophic osteoarthropathy or Touraine-Solente-Golé syndrome. [2] It is mainly characterized by pachyderma (thickening of the skin), periostosis (excessive bone formation) and finger clubbing (swelling of tissue with loss of normal angle between nail and nail bed). [1] [3] This disease affects more men than women.
Hypertrophic osteoarthropathy – Shiny aspect and striation of the nail and skin Schamroth's sign or Schamroth's window test (originally demonstrated by South African cardiologist Leo Schamroth on himself) [ 16 ] is a popular test for clubbing.
One theory is that hypertrophic osteopathy is caused by increased blood flow to the ends of the legs, overgrowth of connective tissue, and then new bone formation surrounding the bones. [6] This is secondary to nerve stimulation by the lung disease. The condition may reverse if the lung mass is removed or if the vagus nerve is cut on the ...
Examples of periosteal reactive bone in selected specimens of Triceratops. A periosteal reaction can result from a large number of causes, including injury and chronic irritation due to a medical condition such as hypertrophic osteopathy, bone healing in response to fracture, chronic stress injuries, subperiosteal hematomas, osteomyelitis, and cancer of the bone.
Hypertrophic osteoarthropathy, primary, autosomal recessive, 2; Melorheostosis; Tumoral calcinosis, hyperphosphatemic, familial, 1; Worth disease; Meningioma of the middle third of the sagittal sinus with large hyperostosis
The diffuse pattern of resorption has a widely diverse differential diagnosis which includes: pyknodysostosis, collagen vascular disease and vasculitis, Raynaud's neuropathy, trauma, epidermolysis bullosa, psoriasis, frostbite, sarcoidosis, hypertrophic osteoarthropathy, acromegaly, and advanced leprosy. [1] [2] [3]
24059 Ensembl ENSG00000174640 ENSMUSG00000032548 UniProt Q92959 Q9EPT5 RefSeq (mRNA) NM_005630 NM_033314 RefSeq (protein) NP_005621 NP_201571 Location (UCSC) Chr 3: 133.93 – 134.05 Mb Chr 9: 102.87 – 102.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Solute carrier organic anion transporter family member 2A1, also known as the prostaglandin transporter (PGT), is a protein ...