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Sm-p80-based vaccine formulation(s) have four effects: Reduction in adult worm numbers; Reduction in egg production (complete elimination of egg induced pathology both in baboons and mice); Protection against acute schistosomiasis; Therapeutic effect on adult worms. This vaccine is now ready for human clinical trials. [5] [6] [7] Another target ...
Schistosoma japonicum is an important parasite and one of the major infectious agents of schistosomiasis.This parasite has a very wide host range, infecting at least 31 species of wild mammals, including nine carnivores, 16 rodents, one primate (human), two insectivores and three artiodactyls and therefore it can be considered a true zoonosis.
In humans, symptoms can include abdominal pain, diarrhea and weight loss. However, many infected individuals may be asymptomatic. Eurytrematosis is diagnosed through fecal examination for the presence of trematode eggs. Treatment typically involves the use of anthelmintic drugs such as praziquantel, which can effectively kill the adult parasites.
Post-treatment monitoring Osteopontin (OPN) is a promising tool for monitoring praziquantel efficacy and post-treatment fibrosis regression as (OPN) expression is modulated by S. mansoni egg antigens and its levels correlate with the severity of schistosomiasis fibrosis and portal hypertension in mice and humans. Praziquantel pharmacotherapy ...
The 1990–2013 Global Burden of Disease Study estimated 5,500 direct deaths from schistosomiasis, [77] while more than 200,000 people were estimated in 2013 to die annually from causes related to schistosomiasis. [78] Another 20 million have severe consequences from the disease. [79] It is the most deadly of the neglected tropical diseases. [80]
Schistosoma mansoni is a water-borne parasite of humans, and belongs to the group of blood flukes (Schistosoma). The adult lives in the blood vessels (mesenteric veins) near the human intestine. It causes intestinal schistosomiasis (similar to S. japonicum, S. mekongi, S. guineensis, and S. intercalatum). Clinical symptoms are caused by the eggs.
Schistosomiasis vaccine; References Further reading. Abdul-Ghani, R; Loutfy, N; Sahn, A; Hassan, A (Apr 2009). "Current chemotherapy arsenal for schistosomiasis ...
Scabies (also sometimes known as the seven-year itch) is a contagious human skin infestation by the tiny (0.2–0.45 mm) mite Sarcoptes scabiei, variety hominis. The word is from Latin: scabere, lit. 'to scratch'. The most common symptoms are severe itchiness and a pimple -like rash. Occasionally, tiny burrows may appear on the skin. In a first-ever infection, the infected person usually ...