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The Common Terminology Criteria for Adverse Events (CTCAE), [1] formerly called the Common Toxicity Criteria (CTC or NCI-CTC), are a set of criteria for the standardized classification of adverse events of drugs and treatment used in cancer therapy. The CTCAE system is a product of the US National Cancer Institute (NCI).
Six types of toxicity data are included in the file: Primary irritation; Mutagenic effects; Reproductive effects; Tumorigenic effects; Acute toxicity; Other multiple dose toxicity; Specific numeric toxicity values such as LD 50, LC 50, TDLo, and TCLo are noted as well as species studied and the route of administration used. For all data the ...
DTP/NCI DTP Open Compound collection National Cancer Institute Development Therapeutics Program Cancer therapeutics Cancer Chemotherapy National Service Center number "DTP/NCI". 250,000 ECHA: REACH database: European Chemicals Agency: EINECS ELINCS NLP: CASNo HPhrases pictograms tonnage "ECHA/REACH". 245,000 EAWAG-BBD Biocatalysis ...
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In addition, toxicity categories may be used for regulatory purposes other than labeling, such as classification for restricted use and requirements for child-resistant packaging. In certain cases, statements based upon the Toxicity Category of the product as diluted for use are also permitted. A Toxicity Category is assigned for each of five ...
The toxicity of the individual congeners may vary by orders of magnitude. With the TEFs, the toxicity of a mixture of dioxins and dioxin-like compounds can be expressed in a single number – the toxic equivalency (TEQ). It is a single figure resulting from the product of the concentration and individual TEF values of each congener. [1]
Epirubicin's toxicity is according to the NCI-CTEP Common Toxicity Criteria, version 2.0. In some studies, patient toxicity reviews were obtained by a diary with the important information before and after each cycle of chemotherapy and their consequences. [16]
These criteria, combined with estimates of exposure, provide the information necessary to evaluate chemical release events for the purpose of taking appropriate protective actions. During an emergency response, these criteria may be used to evaluate the severity of the event, to identify potential outcomes, and to decide what protective actions ...
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