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Benfotiamine (rINN, or S-benzoylthiamine O-monophosphate) is a synthetic, fat-soluble, S-acyl derivative of thiamine (vitamin B1) that is approved in some countries as a medication or dietary supplement to treat diabetic sensorimotor polyneuropathy. Benfotiamine was developed in late 1950s in Japan.
The US Recommended Dietary Allowance for vitamin C for adult women is 76 mg/day and for adult men 90 mg/day. Although Linus Pauling was known for highly respectable research in chemistry and biochemistry, he was also known for promoting the consumption of vitamin C in large doses. [ 25 ]
As of October 2018, this study published in 2016 is still the most recent human study about taking oral Benfotiamine for a long time. 300mg/day benfotiamine given to Alzheimer patients for 18 months. No other doses were tested so it is impossible to know the optimal dose yet. Impressive benefits, but only 5 humans participated in the study!
In 2019, a systematic review and meta-analysis examining the relationship between ‘maternal multivitamin supplementation’ and children being diagnosed with autism spectrum disorder (ASD) was published in Nutritional Research. The research was conducted in the previous year and involved using the ‘random effects’ model on 9 independent ...
Adverse effects found in clinical trials are usually limited to headache and gastrointestinal discomfort when high doses are used. While daily use can result in tolerance and paradoxical drowsiness, increasing the dose is strongly discouraged and side effects can include diarrhea, bladder infections, bronchitis, back pain, abdominal pain, insomnia, constipation, gastroenteritis, headache ...
Outside of rare medical conditions, placebo-controlled studies have generally failed to show benefits of high doses of vitamin B 6. [29] Reviews of supplementing with vitamin B 6 have not found it to be effective at reducing swelling, reducing stress, producing energy, preventing neurotoxicity, or treating asthma. [23]
The book was well received by the public and garnered considerable popular attention, resulting in a rush of vitamin C sales. Paperback editions were issued in 1971 and 1973, and Pauling subsequently authored several related books: Vitamin C and Cancer (1979) and How to Live Longer and Feel Better (1986).
There is a strong advocacy movement for very high doses of vitamin C, yet there is an absence of large-scale, formal trials in the 10 to 200+ grams per day range. The single repeatable side effect of oral megadose vitamin C is a mild laxative effect if the practitioner attempts to consume too much too quickly.
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