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Tajima's D is a population genetic test statistic created by and named after the Japanese researcher Fumio Tajima. [1] Tajima's D is computed as the difference between two measures of genetic diversity: the mean number of pairwise differences and the number of segregating sites, each scaled so that they are expected to be the same in a neutrally evolving population of constant size.
For example it is used to calculate the Tajima's D neutral evolution statistic. A sequence alignment, produced by ClustalO, of mammalian histone proteins. Sequences are the amino acids for residues 120-180 of the proteins. Residues that are conserved across all sequences are highlighted in grey.
Fumio Tajima was born in Ōkawa, in Japan's Fukuoka prefecture, in 1951. [1] [2] He graduated from high school in 1970, completed his undergraduate degree at Kyushu University in 1976, and received a Master's degree from the same institution in 1978. [3]
Comparing the value of the Watterson's estimator, to nucleotide diversity is the basis of Tajima's D which allows inference of the evolutionary regime of a given locus.
Nabi Tajima (田島 ナビ, 1900–2018), Japanese supercentenarian; Naoto Tajima (田島 直人, 1912–1990), Japanese athlete; Nobuhiro Tajima (田嶋 伸博, born 1950), Japanese race car driver; Princess Tajima (但馬皇女, died 708), daughter of Emperor Tenmu of Japan; Renee Tajima-Peña (born 1958), American film director and producer
This test is an advancement over Tajima's D, [2] which is used to differentiate neutrally evolving sequences from those evolving non-randomly (through directional selection or balancing selection, demographic expansion or contraction or genetic hitchhiking).
Tajima's D is based on the expectation that S = theta * x where x is the sum of 1/i for i from 1 to N. Thus, we turn this into a method to estimate theta by noting that theta = E(S)/x. The current version suggests that S/x part is a "normalized" version of segregating sites, and this leads to a mistake in the calculation of D in the example.
Michiji Tajima. Michiji Tajima (Japanese: 田島道治) (July 2, 1885 – December 2, 1968) was a Japanese businessman and educator.He was Grand Steward of the Imperial Household Office (June 5, 1948 – May 31, 1949) and continued as Grand Steward of its successor, the Imperial Household Agency (June 1, 1949 – December 16, 1953).