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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
The symptoms of type 4B hemochromatosis tend to be more severe. They resemble the symptoms of hemochromatosis types 1, 2, and 3. Plasma iron concentration is elevated, and symptoms include joint pain, diabetes, and arrhythmia. Liver iron deposition tends to be greater in type 4B than in type 4A. [5]
Symptoms that emerge early on in the disease are generally less severe, and may include conditions such as fatigue, weakness, skin discoloration, loss of sex drive and joint pain. Late in the disease, people may experience liver disease as well as disease to other major organs as excess iron is deposited over time.
Symptoms of iron overload include fatigue, skin discoloration, and joint and abdominal pain. Can iron pills cause weight gain? There is no direct evidence that iron pills cause weight gain ...
FYI: Signs of iron overload include fatigue, an irregular heartbeat, joint pain, stomach pain and more. Signs of an iron deficiency can be similar—like fatigue—and also include pale or yellow ...
Overview. Joint pain is a common symptom we all experience at some point or another. Painful joints can have a significant impact on quality of life and the ability to do daily activities.
Haemochromatosis is protean in its manifestations, i.e., often presenting with signs or symptoms suggestive of other diagnoses that affect specific organ systems.Many of the signs and symptoms below are uncommon, and most patients with the hereditary form of haemochromatosis do not show any overt signs of disease nor do they have premature morbidity, if they are diagnosed early, but, more ...
One of Weyand’s clinical interests is in iron deficiency, the symptoms of which include extreme fatigue, weakness, headache, lightheadedness, ... a.k.a. iron overload disorder. The rates are ...
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