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  2. Association mapping - Wikipedia

    en.wikipedia.org/wiki/Association_Mapping

    In genetics, association mapping, also known as "linkage disequilibrium mapping", is a method of mapping quantitative trait loci (QTLs) that takes advantage of historic linkage disequilibrium to link phenotypes (observable characteristics) to genotypes (the genetic constitution of organisms), uncovering genetic associations.

  3. Linkage disequilibrium - Wikipedia

    en.wikipedia.org/wiki/Linkage_disequilibrium

    Once linkage disequilibrium has been calculated for a dataset, a visualization method is often chosen to display the linkage disequilibrium to make it more easily understandable. The most common method is to use a heatmap, where colors are used to indicate the loci with positive linkage disequilibrium, and linkage equilibrium. This example ...

  4. Linkage disequilibrium score regression - Wikipedia

    en.wikipedia.org/wiki/Linkage_disequilibrium...

    In statistical genetics, linkage disequilibrium score regression (LDSR [1] or LDSC [2]) is a technique that aims to quantify the separate contributions of polygenic effects and various confounding factors, such as population stratification, based on summary statistics from genome-wide association studies (GWASs).

  5. Genome-wide association study - Wikipedia

    en.wikipedia.org/wiki/Genome-wide_association_study

    Hence, GWAS is a non-candidate-driven approach, in contrast to gene-specific candidate-driven studies. GWA studies identify SNPs and other variants in DNA associated with a disease, but they cannot on their own specify which genes are causal. [1] [2] [3] The first successful GWAS published in 2002 studied myocardial infarction. [4]

  6. Transcriptome-wide association study - Wikipedia

    en.wikipedia.org/wiki/Transcriptome-wide...

    A genome-wide association study, or GWAS, is a genetic tool that uses single nucleotide polymorphisms, or SNPs, to identify if a trait or disease is linked to a specific genetic variant. By observing if frequencies of a specific variant are more commonly associated, or higher than expected, with the given trait; an association is developed ...

  7. Tag SNP - Wikipedia

    en.wikipedia.org/wiki/Tag_SNP

    The most commonly used approach, block-based method, exploits the principle of linkage disequilibrium observed within haplotype blocks. [12] Several algorithms have been devised to partition chromosomal regions into haplotype blocks which are based on haplotype diversity , LD , four-gamete test and information complexity and tag SNPs are ...

  8. Trump gives allies Devin Nunes, Richard Grenell key roles

    www.aol.com/news/trump-taps-truth-social-ceo...

    WASHINGTON (Reuters) -U.S. President-elect Donald Trump on Saturday named his social media platform CEO Devin Nunes to lead an intelligence advisory panel and said his former intelligence chief ...

  9. Genetic correlation - Wikipedia

    en.wikipedia.org/wiki/Genetic_correlation

    Genetic correlations can arise due to: [19] linkage disequilibrium (two neighboring genes tend to be inherited together, each affecting a different trait); biological pleiotropy (a single gene having multiple otherwise unrelated biological effects, or shared regulation of multiple genes [39])