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An extract of maritime pine bark called Pycnogenol bears 65–75 percent proanthocyanidins (procyanidins). [10] Thus a 100 mg serving would contain 65 to 75 mg of proanthocyanidins (procyanidins). Proanthocyanidin glycosides can be isolated from cocoa liquor .
Maritime pine bark extract is an extract from the bark of Pinus pinaster which is used as a dietary supplement. It is composed mostly of proanthocyanidins . [ 1 ] Pycnogenol is a trademarked name for a standardized preparation that contains 70% procyanidins .
Pycnogenol is a dietary supplement derived from extracts from maritime pine bark that contains 70% procyanidins, and is marketed with claims it can treat many conditions. The medical evidence is insufficient to support its use for the treatment of seven different chronic disorders .
Pycnogenol is a dietary supplement derived from extracts from maritime pine bark, is standardised to contain 70% procyanidin and is marketed with claims it can treat many conditions; however, according to a 2020 Cochrane review, the evidence is insufficient to support its use for the treatment of any chronic disorder. [12] [13]
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Procyanidin C2 is the subtype of extract most effective. [11] Experiments showed that both procyanidin C2 and Pycnogenol (French maritime pine bark extract) increase TNF-α secretion in a concentration- and time-dependent manner. These results demonstrate that procyanidins act as modulators of the immune response in macrophages.
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