Search results
Results from the WOW.Com Content Network
The telomere was first discovered by biologist Hermann Joseph Muller in the early 20th century. [4] However, experiments by Elizabeth Blackburn, Carol Greider, and Jack Szostak in the 1980s led to the successful discovery of telomerase (the enzyme responsible for maintaining telomere length) and a better understanding of telomeres. [5] [6] [7]
Researchers measured the length of each of the participants’ telomeres (protective DNA caps at the ends of chromosomes). Telomeres shorten with age, and the rate of shortening may indicate how ...
[49] [50] There is a Web-based Analyser of the Length of Telomeres , software processing the TRF pictures. [51] A Real-Time PCR assay for telomere length involves determining the Telomere-to-Single Copy Gene (T/S) ratio, which is demonstrated to be proportional to the average telomere length in a cell. [52]
They then used α factor to block cells with induced short telomeres in late G1 phase and measured the change in telomere length when the cells were released under a variety of conditions. They found that when the cells were released and concurrently treated with nocodazole , a G2/M phase cell cycle inhibitor, telomere length increased for the ...
As the cell divides, the telomeres on the ends of chromosomes shorten. The Hayflick limit is the limit on cell replication imposed by the shortening of telomeres with each division. This end stage is known as cellular senescence. The Hayflick limit has been found to correlate with the length of the telomeric region at the end of chromosomes.
While increasing the amount of exercise, decreasing stress, and tobacco use, and maintaining a balanced sleep schedule, Blackburn explains that telomere length can be maintained, leading to a decrease in cell aging. [36] Blackburn also tells readers to be wary of clinical pills that proclaim to lengthen or telomeres and protect the body from aging.
The “spacing effect” refers to a phenomenon whereby learning, or the creation of a memory, occurs more effectively when information, or exposure to a stimulus, is spaced out.
Oxidative stress can damage DNA replication and inhibit repair through many complex processes, including telomere shortening in DNA components. [25] Each time a somatic cell replicates, the telomeric DNA component shortens. As telomere length is partly inheritable, [25] there are individual differences in the age of onset of cognitive decline.