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Immune tolerance encompasses the range of physiological mechanisms by which the body reduces or eliminates an immune response to particular agents. It is used to describe the phenomenon underlying discrimination of self from non-self, suppressing allergic responses, allowing chronic infection instead of rejection and elimination, and preventing ...
As of 2024, she is an emeritus professor at Scripps Research, and serves on the advisory boards of the La Jolla Institute for Immunology and the San Diego Biomedical Research Institute. [3] [4] Her research has focused on immune tolerance and autoimmunity, particularly type 1 diabetes, as well as the immune response to tumors.
His research is focused on understanding T cell activation and immune tolerance in autoimmunity and organ transplantation. In April 2016, he co-founded and served as the president and CEO of the Parker Institute for Cancer Immunotherapy,. [3] In 2019, he co-founded and is Chief Executive Officer and President of Sonoma Biotherapeutics. [4]
Sir Peter Brian Medawar OM CH CBE FRS (/ ˈ m ɛ d ə w ər /; 28 February 1915 – 2 October 1987) [1] was a British biologist and writer, whose works on graft rejection and the discovery of acquired immune tolerance have been fundamental to the medical practice of tissue and organ transplants.
Burnet and Medawar were co-recipients of the 1960 Nobel Prize in Physiology or Medicine for this work, as it provided the experimental basis for inducing immune tolerance, [95] thereby allowing the transplantation of solid organs. Burnet and Medawar were able to coordinate their work effectively despite their rather different personalities and ...
Hugh Auchincloss, Jr. (/ ˈ ɔː k ɪ n k l ɒ s / AW-kin-kloss; born March 15, 1949) is an American immunologist and physician who served as the acting director of the National Institute of Allergy and Infectious Diseases from January to August 2023. Previously, he was the principal deputy director of the NIAID, from 2006 to 2022.
Immune tolerance is maintained by central and peripheral tolerance. During central tolerance, T-cells are selected in the thymus and allowed to enter the periphery based on the ability of the T-cell to recognize self-peptides (via its TCR) being presented in the context of self-MHC. If the TCR binds the peptide-MHC complex with high affinity ...
Conducts research into the molecular basis of cytokine action to define the mechanisms by which these mediators regulate processes such as development, differentiation, memory, tolerance and homeostasis in immune cells. The section also studies patients with primary immunodeficiency and autoinflammatory syndromes.