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In July 2016 α-PiHP was first identified as a designer drug [2] when it was reported to the EMCDDA by a forensic laboratory in Slovenia. [3] [4] It is a positional isomer of pyrovalerone, with the methyl group shifted from the 4-position of the aromatic ring to the 4-position of the acyl chain. Similarly to other cathinones, use of α-PiHP can ...
4-Pyrrolidinylpyridine is an organic compound with the formula (CH 2) 4 NC 5 H 4 N. The molecule consists of a pyrrodinyl group ((CH 2) 4 N-) attached via N to the 4-position of pyridine. It is a white solid. The compound has attracted interest because it (pK a = 9.58) is more basic than dimethylaminopyridine (pK a = 9.41). [1] It is a popular ...
Pyrrolidine, also known as tetrahydropyrrole, is an organic compound with the molecular formula (CH 2) 4 NH. It is a cyclic secondary amine , also classified as a saturated heterocycle . It is a colourless liquid that is miscible with water and most organic solvents.
Methylenedioxypyrovalerone (abbreviated MDPV, and also called monkey dust [3]) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI).
α-Pyrrolidinohexiophenone is a longer chain homologue of α-PVP, having an extra carbon on the alkyl side chain.Regarding the potency of alpha-PHP in the brain, chemist Michael H. Baumann of the Designer Drug Research Unit (established by Baumann [8]) of the National Institute on Drug Abuse stated: "alpha-PHP might be even more potent than alpha-PVP"; this statement is based on laboratory ...
Pyrovalerone (Centroton, 4-Methyl-β-keto-prolintane, Thymergix, O-2371) [2] is a central nervous system (CNS) stimulant that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI).
4'-Fluoro-α-pyrrolidinopentiophenone (also known as O-2370, FPVP and 4-Fluoro-α-PVP) is a stimulant drug of the cathinone class which has been reported as a novel designer drug. [ 1 ] [ 2 ] [ 3 ] Legality
The structure-activity relationship of the drug class has been explored to a reasonable extent. The optimal substitution pattern is fairly tightly defined (i.e. N,N-diethyl on the amine nitrogen, 4-ethoxy on the benzyl ring and 5-nitro on the benzimidazole ring), but even derivatives incorporating only some of these features are still potent opioids.