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1-Phenylpiperazine (1-PP or PP) is a simple chemical compound and drug featuring a phenyl group bound to a piperazine ring. [1] The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class. [2] It is a rigid analogue of amphetamine.
Piperazine is freely soluble in water and ethylene glycol, but insoluble in diethyl ether. It is a weak base with two pK b of 5.35 and 9.73 at 25 °C.; the pH of a 10% aqueous solution of piperazine is 10.8–11.8. Piperazine readily absorbs water and carbon dioxide from the air.
Phenylhydrazine is used to prepare indoles by the Fischer indole synthesis, which are intermediates in the synthesis of various dyes and pharmaceuticals. Phenylhydrazine is used to form phenylhydrazones of natural mixtures of simple sugars in order to render the differing sugars easily separable from each other. [9]
The alkylation of 2-chloro-10-(3-chloropropyl)phenothiazine [2765-59-5] (1) with Piperazine (2) gives N-Desmethylprochlorperazine [40323-85-1] (3). Further alkylation with 2-Bromoethyl acetate [927-68-4] ( 4 ) gives Thiopropazate ( 5 ).
Thieme Synthesis: [1] Patents: [3] [4] [5]. Method E: The reaction between 2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethanol [40004-29-3] (1) and Isatoic ...
Jimmy Butler #22 of the Miami Heat looks on during the game against the Toronto Raptors on December 1, 2024 at the Scotiabank Arena in Toronto, Ontario, Canada.
N-Methylpiperazine is a common building block used in organic synthesis. [2] For example, N-methylpiperazine is used in the manufacture of various pharmaceutical drugs including cyclizine, [3] meclizine, and sildenafil. The lithium salt, lithium N-methylpiperazide, is used as a reagent in organic synthesis for protection of aryl aldehydes. [4]
The hearing came a day after Mangione was arrested in Altoona. Police searched Mangione and found a fake New Jersey driver's license and a "semi-automatic pistol" with a silencer, both made by a ...